Endocrine Abstracts

The aim of the study was to analyze the influence of feed from different production systems on food intake, body chemical composition and plasma leptin concentrations in rats. It is expected, that organically produced feed influences positively rat organism, in that hormone balance. Leptin regulates energy intake and expenditure, as well as basic functions of many tissues.The experiment was conducted in 104 Wistar male rats divided into 16 dietary groups...

Little is known about the prevalence and significance of islet cell immunity in elderly patients with type 2 diabetes. The low antibody titers against islet-cell antigens in LADA elderly patients may be a sign of a less aggressive autoimmune diabetes.The objective: To establish the changing frequency and titers of GADA and IAA in elderly diabetics.Material: 83(56F;27M)diabetic patients (60–91 y) divided in age related groups. ...

In the opinion of the World Health Organization the obesity will become one of four major epidemics of the 21st century. The most important factor for its occurrence is the lifestyle.The aim of the research was to analyse the body mass index (BMI) of pre-school children and their parents and the components of their lifestyle, such as diet, sports and free time activities.Material and Methods: The two-stage study included 537 childr...

IntroductionTrue resistance to cabergoline in patients with hyperprolactinaemia has only rarely been reported. We describe a patient with macroprolactinoma who initially responded to cabergoline, but then developed a progressive increase in PRL levels.Clinical caseA 78-year-old male presenting with headache and left temporal hemianopia was found to have a macroprolactinoma with suprasellar/cavernous sinus ext...

It is a well-known fact that vitamin D has an impact on many tissues of human body. Recent studies showed that vitamin D deficiency has an influence on inflamation indicators in several endocrine diseases (for example PCOS, graves disease). The aim of the study was to demonstrate correlation between 25-OH vitamin D concentration and chosen inflammation indicators (C-reactive protein and insulin) in patients with non-functioning adrenal incidentalomas. Seventy-one patients hosp...

Abstract: Up to 96% of changes detected in adrenal glands are non-functioning adrenal incidentalomas. Adrenal masses are associated with increased risk of metabolic syndrome (MS). Studies demonstrate that new anthropometric parameters can be useful indicators of disturbances in glucose and lipid metabolism in various diseases. The purpose of the study was to determine antropometric parameters and its relationship with MS factors according to the criteria of the International D...

In patients with Graves disease and Graves’ orbitopathy (GO), the diagnosis was based on clinical activity score (CAS), TSH-receptor antibodies, orbital MRI assesment. Thyreometabolic status was assessed by TSH, FT4, FT3. Before the administration of high-dose intravenous glucocorticoids oral glucose tolerance test (OGTT) was performed obligatory. The patient with confirmed diabetes were excluded form the study. Acute hyperglycaemia was diagnosed at the glucose concentrat...

Objectives: The aim of this systematic review was assessment of clinical efficacy of pegvisomant (PEG) in the treatment of adult patients (age ≥18 years) with acromegaly.Methods: The review was conducted according to the Cochrane Collaboration guidelines and polish recommendations of The Agency for Health Technology Assessment and Tariff System. Since acromegaly is a rare disease, not only randomized clinical trials (RCTs), but also real world data...

Background: Prolonged exposure to excessive concentrations of GH and IGF-1 in acromegaly continues to affect patients’ appearance and negatively influences their self-evaluation, personal relations and morbidity. Besides chronic GH/IGF-1 excess could be deleterious to the brain through many mechanisms.Objectives: The aim of the study was to evaluate the influence of acromegaly on the prevalence and the severity of depressive symptoms in patients wit...

Polycystic ovary syndrome is associated with lipid and carbohydrate metabolism disorders, leading to obesity and insulin resistance. The aim of the study was to asses the correlation among anthropometric parameters, metabolic markers (lipid and carbohydrate profiles) and CRP as inflammatory indicator in women with Polycystic Ovary Syndrome. The study consists of 43 women diagnosed with Polycystic Ovary Syndrome based on 2003 Rotterdam criteria. The patients were hospitalized i...